✦ LIBER ✦

Synthesis of a 125I labelled azido-substituted glibenclamide analogue for photoaffinity labelling of the sulfonylurea receptor

✍ Scribed by Franz Chudziak; Mathias Schwanstecher; Hartmut Laatsch; Uwe Panten

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 286 KB
Volume: 34
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580340713

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✦ Synopsis

Abstract

N‐{4‐(2‐{4‐Azido‐2‐hydroxy‐5‐[^125^I]iodobenzamido}ethyl)benzenesul]‐N′‐cyclohexylurea has been prepared as a novel photoaffinity ligand for the sulfonylurea receptor. This involved synthesis of a 4‐azidosalicyloyl analogue of glibenclamide and treatment of the analogue with Na^125^I and chloramine‐T. Purification by HPLC gave the radiolabelled sulfonylurea in 56% radiochemical yield and high specific activity (2130 Ci/mmol).

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