✦ LIBER ✦
Synthesis of an [125I]-labelled derivative of MK-571, a tool for LTD4 receptor studies
✍ Scribed by Chun-Sing Li; Yves Leblanc; Robert Zamboni; Robert N. Young
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 292 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
An [^125^I]‐labelled derivative of MK‐571 2 was synthesized from the arylstanne derivative 11 in 50% radiochemical yield. Compound 2 is a useful tool for LTD~4~ receptor studies. The arylstanne intermediate 11 was obtained from the coupling reaction of (±)‐3‐[[[3‐[2‐(7‐chloro‐2‐quinolinyl)‐(E)‐ethenyl]phenyl][[3‐[(3‐aminopropyl)amino]‐3‐oxopropyl]thio]methyl]thio]propionic acid 10 with N‐hydroxysuccinimidyl 4‐trimethylstannylphenylacetate 3. The synthesis of 3 could be easily achieved from 4‐bromophenethyl alcohol.