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Synthesis of 99mTc(CO)3-mebrofenin via [99mTc(OH2)3(CO)3]+ precursor and comparative pharmacokinetics studies with 99mTc-mebrofenin

✍ Scribed by Kanchan Kothari; Sangeeta Joshi; Meera Venkatesh; N. Ramamoorthy; M.R.A. Pillai

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
134 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

The organometallic precursor fac-[ 99m Tc(OH 2 ) 3 (CO) 3 ] + was reacted with trimethyl-bromoacetanilido-iminodiacetic acid (mebrofenin) in phosphate buffered saline (pH 7) at 708C for 1 h to produce the complex, 99m Tc(CO) 3mebrofenin, in >95% yields. High performance liquid chromatography analysis indicated the formation of a single species. In vitro studies of 99m Tc(CO) 3 -mebrofenin showed that the complex is stable for 24 h. No decomposition or alteration of the complex was observed in the presence of excess amount of cysteine and histidine. 99m Tc-mebrofenin was also prepared for comparative evaluation by the conventional method using a ready to use kit HPLC analysis of this complex showed presence of two species. Biodistribution studies in normal Swiss mice with 99m Tc(CO) 3 -mebrofenin showed hepatobiliary clearance. However, the retention in liver was higher (13% at 1 h p.i.) as compared to that of 99m Tc-mebrofenin (3.4% at 1 h p.i.).

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