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Synthesis, Radiolabelling and in vitro Stability Study of 99mTc(CO)+3 Labeled Dendrimer PAMAM-Folic Acid Conjugate

✍ Scribed by Yuanqing Zhang; Xiaoping Xu; Yanhong Sun; Yumei Shen

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 85 KB
Volume: 28
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.201190019

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✦ Synopsis

Abstract

Dendrimer polyamidoamine generation five‐folic acid conjugate was synthesesed and radiolabelled with fac‐[^99m^Tc(CO)~3~(H~2~O)~3~]^+^, its in vitro stability was evaluated further. Both of the labeling yield and radiochemical purity of the G5‐FA‐DTPA‐^99m^Tc(CO)~3~ conjugate exceeded 95%. More than 95.7% and 93.1% of the conjugate still keeps its original structure in PBS and new‐born calf serum solution respectively.

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