✦ LIBER ✦

Synthesis of 9-[3-pyridylmethyl]-9-deazaguanine[2-14carbon]

✍ Scribed by Ved P. Pathak; John A. Montgomery

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 167 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330202

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✦ Synopsis

Abstract

^14^C labeled 2‐amino‐7‐(3‐pyridylmethyl)‐4‐oxo‐3__H__,5__H__‐pyrrolo[3,2‐d]pyrimidine(6) was synthesized starting from methyl 3‐amino‐4‐(3‐pyridylmethyl)‐1__H__ ‐pyrrolo‐2‐carboxylate. This pyrrole on condensation with ^14^C labeled benzoylisothiocyanate followed by methylation gave methyl 3‐[N‐benzoyl‐S‐methylisothiocarbamoyl)‐amino]‐4‐(3‐pyridylmethyl)‐1__H__‐pyrrole‐2‐carboxylate [3‐^14^C] (5), which on reaction with methanolic ammonia furnished the title compound(6).

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