An Improved Synthesis of 9-Deazaguanine.
✍ Scribed by Mao-Chin Liu; Mei-Zhen Luo; Diane E. Mozdziesz; Alan C. Sartorelli
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 127 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
For Abstract see ChemInform Abstract in Full Text.
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## Abstract The syntheses of __N__^7^‐glycosylated 9‐deazaguanine **1a** as well as of its 9‐bromo and 9‐iodo derivatives **1b**,**c** are described. The regioselective 9‐halogenation with __N__‐bromosuccinimide (NBS) and __N__‐iodosuccinimide (NIS) was accomplished at the protected nucleobase **4a