Synthesis of 7-dehydrocholesterol through a palladium catalyzed selective homoannular conjugated diene formation
โ Scribed by Diane Dugas; Jean Michel Brunel
- Book ID
- 104057025
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 288 KB
- Volume
- 253
- Category
- Article
- ISSN
- 1381-1169
No coin nor oath required. For personal study only.
โฆ Synopsis
The development of a selective palladium catalyzed homoannular conjugated diene formation and its subsequent application to the synthesis of 7-dehydrocholesterol is reported.
๐ SIMILAR VOLUMES
A terminal conjugated diene system is present in certain natural products. Also it can be converted to 2-olefin or 3-olefin by selective reduction. But there appeared few synthetic methods for this system. For example, a rapidly developing coupling reaction of vinyl halides with various vinyl metal
## Abstract The linker chain length in the ligand decides on the formation of the allenes or propargyl derivatives, with the former obtained predominantly with the shorter chain (dppe) and the latter being preferred using Ph~2~Pโ(CH~2~)~6~โPPh~2~ as a ligand.