Synthesis of 6-Acetamido-5-amino- and -5-guanidino-3,4-dehydro- N -(2-ethylbutyryl)- 3-piperidinecarboxylic Acids Related to Zanamivir and Oseltamivir, Inhibitors of Influenza Virus Neuraminidases
β Scribed by Shitara, Eiki; Nishimura, Yoshio; Nerome, Kuniaki; Hiramoto, Yasuaki; Takeuchi, Tomio
- Book ID
- 118256673
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 65 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The novel influenza virus neuraminidase inhibitor GGI 67 (5-acetylamino-4-guan~d~no-2,6-anhydro-3,4,5-tr~deoxy-D-g~ycero-~-galacto-non-2-eno~c acid) was labelled with "C for use in positron emission tomographic studies of drug deposition following intranasal or inhaled administration. ["C]GG167 was
N-Propylcarboxamides la,b-3a,b have been synthesised from 2,3-didehydro-2,4-dideoxy-4amino-N-acetylneuraminic acid 4. The tertiary amides 2a,b-3a,b are highly potent but selective inhibitors of influenza A sialidase. The exceptional inhibitory activity of the dipropylamides 3a and 3b against influen