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Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidase

✍ Scribed by Steven L. Sollis; Paul W. Smith; Peter D. Howes; Peter C. Cherry; Richard C. Bethell

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 221 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00318-6

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✦ Synopsis

N-Propylcarboxamides la,b-3a,b have been synthesised from 2,3-didehydro-2,4-dideoxy-4amino-N-acetylneuraminic acid 4. The tertiary amides 2a,b-3a,b are highly potent but selective inhibitors of influenza A sialidase. The exceptional inhibitory activity of the dipropylamides 3a and 3b against influenza A shows that the 6-dipropylcarboxamide substituent is preferable to the polar glycerol sidechain found in the related sialidase inhibitors GG167 and 4.

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