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Synthesis of (4R*,5S*)-5-acetylamino-4-diethylcarbamoyl-5,6-dihydro-4H-pyran-2-carboxylic acid and its inhibitory action against influenza virus sialidases

✍ Scribed by Sean A Kerrigan; Robin G Pritchard; Paul W Smith; Richard J Stoodley

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
99 KB
Volume
42
Category
Article
ISSN
0040-4039

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## Abstract Following a known procedure, a mixture of (βˆ’)‐(2__S__,3__R__)‐ and (+)‐(2__R__,3__R__)‐2,3‐epoxy‐citronellols (**5**) was prepared from (βˆ’)‐(__R__)‐linalool (**3**) __via__ epoxy alcohol **4** and then reduced to (βˆ’)‐(__R__)‐3‐hydroxy‐citronellol (**6**). Sensitized photooxygenation of