✦ LIBER ✦

Synthesis of (4R,5R)-4-acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R,4R)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid: new inhibitors of influenza virus sialidases

✍ Scribed by Sean A Kerrigan; Paul W Smith; Richard J Stoodley

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 81 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00798-5

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✦ Synopsis

4R*,5R*)-4-Acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R*,4R*)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid have been synthesised using a Diels-Alder tactic; both compounds are selective inhibitors of influenza A sialidase, the latter compound being particularly potent.

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✦ Synopsis

Synthesis of (4R,5R)-4-acetylamino-5-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid and (3R,4R)-4-acetylamino-3-diethylcarbamoylcyclohex-1-ene-1-carboxylic acid: new inhibitors of influenza virus sialidases