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ChemInform Abstract: Novel Inhibitors of Influenza Sialidase Related to GG167. Synthesis of 4-Amino- and 4-Guanidino-4H-5.6-dihydropyran-2-carboxy-6-N- propylcarboxamides; Selective Inhibitors of Influenza A Virus Sialidase.

✍ Scribed by S. L. SOLLIS; P. W. SMITH; P. D. HOWES; P. C. CHERRY; R. C. BETHELL


Book ID
112041123
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
27
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES


Novel inhibitors of influenza sialidase
✍ Steven L. Sollis; Paul W. Smith; Peter D. Howes; Peter C. Cherry; Richard C. Bet πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 221 KB

N-Propylcarboxamides la,b-3a,b have been synthesised from 2,3-didehydro-2,4-dideoxy-4amino-N-acetylneuraminic acid 4. The tertiary amides 2a,b-3a,b are highly potent but selective inhibitors of influenza A sialidase. The exceptional inhibitory activity of the dipropylamides 3a and 3b against influen

Novel inhibitors of influenza sialidases
✍ Paul W. Smith; Steven L. Sollis; Peter D. Howes; Peter C. Cherry; Kevin N. Coble πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 289 KB

The structure-activity relationships of a series of 4-amino and guanidino-4H-pyran-2carboxylic acid 6-carboxamides are described. These compounds represent a new class of inhibitor of influenza sialidases and are particularly active against influenza A sialidase. The binding of the Nphenethyl-N-prop