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Synthesis of N-{4-[(2,4-Diamino-5-methyl-4,7-dihydro-3H- pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-l-glutamic Acid and N-{4-[(2-Amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin- 6-yl)thio]benzoyl}-l-glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase and as Potential Antitumor Agents

✍ Scribed by Gangjee, Aleem; Lin, Xin; Kisliuk, Roy L.; McGuire, John J.

Book ID: 111930199
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 561 KB
Volume: 48
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm058234m

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