Synthesis of 5′-phosphonate linked thymidine deoxyoligonucleotides
✍ Scribed by Thomas Kofoed; Marvin H. Caruthers
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 185 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Nucleoside H-Phosphonates are used directly in the synthesis of H-phosphonate linked deoxyoligonucleotides. A rapid and simplified procedure for the synthesis of deoxyoligonucleotides is described. Ribonucleoside H-phosphonate I. was introduced by Todd to prepare diribonucleotide 1 phosphate 4 (Sche
The synthesis of novel 5%-DMT-and 5%-MMT-protected 3%-methylene H-phosphonate thymidines 1-6, having methoxy, fluoro, hydrogen, and methoxyethoxy substituents at the 2%-position is reported.
A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehy
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
## Abstract Condensation of N^3^‐benzoyl‐5′‐O‐dimethoxytrityl‐3′‐O‐(4‐penten‐1‐oxymethyl)‐thymidine with N^3^‐benzoyl‐3′‐O‐methoxyacctyl‐thymidine, in the presence of N‐iodosuccinimide, afforded a fully‐protected thymidine dimer having an internucleosidic‐(3′‐5′)‐methylene linkage. The latter was u