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Facile synthesis of phosphonamidate- and phosphonate-linked phosphonopeptides

✍ Scribed by Nanyan Fu; Qihan Zhang; Lifang Duan; Jiaxi Xu

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 125 KB
Volume: 12
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.727

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✦ Synopsis

A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehydes, and methyl dichlorophosphite, followed by aminolysis with amino acid esters or alcoholysis with hydroxy esters.

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