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Synthesis of oligodeoxynucleotides containing thymidines linked via an internucleosidic-(3′-5′)-methylene bond

✍ Scribed by G. H. Veeneman; G. A. van der Marel; H. van den Elst; J. H. van Boom

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 263 KB
Volume: 109
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19901090712

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✦ Synopsis

Abstract

Condensation of N^3^‐benzoyl‐5′‐O‐dimethoxytrityl‐3′‐O‐(4‐penten‐1‐oxymethyl)‐thymidine with N^3^‐benzoyl‐3′‐O‐methoxyacctyl‐thymidine, in the presence of N‐iodosuccinimide, afforded a fully‐protected thymidine dimer having an internucleosidic‐(3′‐5′)‐methylene linkage. The latter was utilized in the preparation, in solution and on a solid support, of DNA‐fragments containing one or more T‐CH~2~‐T dimer(s).

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