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Synthesis of (3′→5′) methylene acetal linked dinucleosides containing cytosine bases

✍ Scribed by P. J. L. M. Quaedflieg; G. A. van der Marel; E. Kuyl-Yeheskiely; J. H. van Boom


Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
191 KB
Volume
110
Category
Article
ISSN
0165-0513

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## Abstract Condensation of N^3^‐benzoyl‐5′‐O‐dimethoxytrityl‐3′‐O‐(4‐penten‐1‐oxymethyl)‐thymidine with N^3^‐benzoyl‐3′‐O‐methoxyacctyl‐thymidine, in the presence of N‐iodosuccinimide, afforded a fully‐protected thymidine dimer having an internucleosidic‐(3′‐5′)‐methylene linkage. The latter was u