✦ LIBER ✦

Nucleoside h-phosphonates: Valuable intermediates in the synthesis of deoxyoligonucleotides

✍ Scribed by B.C. Froehler; M.D. Matteucci

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 250 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)85507-0

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✦ Synopsis

Nucleoside H-Phosphonates are used directly in the synthesis of H-phosphonate linked deoxyoligonucleotides. A rapid and simplified procedure for the synthesis of deoxyoligonucleotides is described. Ribonucleoside H-phosphonate I. was introduced by Todd to prepare diribonucleotide 1 phosphate 4 (Scheme 1) . -An intermediate diribonucleoside H-phosphonate (2) was isolated and oxidized with N-chlorosuccinimide (NCS, Scheme 1). After 28 years this condensation

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