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Synthesis of 5-hydroxymethyl-11-methyl-6H-pyrido[4,3-b]carbazole and 5-formyl-11-methyl-6H-pyrido[4,3-b]carbazole (17-oxoellipticine)

✍ Scribed by Ross Bruce S; Archer Sydney

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
181 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

A synthesis of 5-hydroxymethyl-ll-methyl-6H-pyrido[4,3-b]carbazole and the correspondinq 5-formvl derivative. 17-oxoellioticine.3 is described, the key feature of which-is the use of the KrohnkeI aldehyde synthesis to effect the debenzylation of a p-nitrobenzyl-pyridinium salt under mild conditions.

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