Synthesis and Anticancer Activity of New 1-Substituted-6H-pyrido[4,3-b]carbazole Derivatives
✍ Scribed by Beata Tylińska; Ryszard Jasztold-Howorko; Henryk Mastalarz; Katarzyna Szczaurska-Nowak; Joanna Wietrzyk
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 513 KB
- Volume
- 341
- Category
- Article
- ISSN
- 0365-6233
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📜 SIMILAR VOLUMES
A synthesis of 5-hydroxymethyl-ll-methyl-6H-pyrido[4,3-b]carbazole and the correspondinq 5-formvl derivative. 17-oxoellioticine.3 is described, the key feature of which-is the use of the KrohnkeI aldehyde synthesis to effect the debenzylation of a p-nitrobenzyl-pyridinium salt under mild conditions.
The aza Wtitig-type reaction of iminophosphorane 3, ethyl a-[(triphenylphosphoranylldane) amino]-p-[3-(g-methyl)catbazolyI)acryiafe with Isocyanates leads to the corresponding pyrido[4,3-c]carbazoles 5. Slmilariy. iminophosphorane 8 Undergoes pyrido annelahon by reaction with isocyanales to give the