Synthesis of 5-azacytidine-6-13C and -6-14C
✍ Scribed by Chan, Kenneth K.; Staroscik, James A.; Sadee, Wolfgang
- Book ID
- 120077258
- Publisher
- American Chemical Society
- Year
- 1977
- Tongue
- English
- Weight
- 397 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The condensation of ethyl acetoacetate‐^13^C~4~ and ethyl bromoacetate‐^13^C~2~ afforded, in seven steps, (1,2,3,4,5‐^13^C~5~) 5‐(diethylphosphono)‐2‐pentanone ethylene ketal 9. The reaction of this labelled compound with 7‐[[(1,1‐dimethylethyl)‐dimethylsilyl]oxy]‐1,6,6a,7,8,9,9a, 9b‐oc
6-14C]Nitrendipine synthesis started from barium[14]carbonate, which was converted to [ 1-14C] acetyl chloride. The acid chloride was condensed with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione). The resulting intermediate was treated with boiling methanol to give methyl [ 3-14C]acetoacetate.
## Abstract ^3^H‐Sch 58235 was prepared at a specific activity of 29.1 Ci/mmol by Ir(COD)(Cy~3~P)PyPF~6~ catalysed exchange with tritium gas. ^14^C‐Sch 58235 was prepared in three steps from __p__‐hydroxy[ring‐U‐^14^C]benzaldehyde with an overall radiochemical yield of 21%. ^13^C~6~‐Sch 58235 was s
D-(1,5,6-13C3)Glucose (7) has been synthesized by a six-step chemical method. D-(1,2-13C2)Mannose (1) was converted to methyl D-(1,2-13C2)mannopyranosides (2), and 2 was oxidized with Pt-C and O2 to give methyl D-(1,2-13C2)mannopyranuronides (3). After purification by anion-exchange chromatography,
## Abstract Uracil‐6‐^14^C (**7**). prepared in high radiochemical yield by conventional methods. has been converted to 5‐fluororacil ‐6‐^14^C (**9**) in over 90% yield using trifluoromethylhypofluorite. The use of this recently introduced reagent eliminates the necessity of preparing **9** from fl