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An improved synthesis of 5-fluorouracil-6-14C

✍ Scribed by C. W. Perry; W. Burger; G. J. Bader; A. A. Liebman

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
240 KB
Volume
11
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Uracil‐6‐^14^C (7). prepared in high radiochemical yield by conventional methods. has been converted to 5‐fluororacil ‐6‐^14^C (9) in over 90% yield using trifluoromethylhypofluorite. The use of this recently introduced reagent eliminates the necessity of preparing 9 from fluorinated precursors.

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