✍ Scribed by M. Jarman; G. N. Taylor
No coin nor oath required. For personal study only.
A high yielding synthesis of 5,5‐dideuterocyclophosphamide is described which involves the base catalysed deuterium exchange of 3‐hydroxypropionitrile and subsequent medium pressure catalytic hydrogenation to yield 1‐amino‐2,2‐dideuteropropan‐3‐ol. This compound is condensed with N,N‐bis(2‐chloroethyl)‐phosphoramidic dichloride to yield pure 5,5‐dideuterocyclophosphamide which is readily isolated as a crystalline monohydrate.
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