## Abstract The high yield, four‐step synthesis of catechol‐U‐^14^C from benzene‐U‐^14^C is described. Intermediates in the preparation include phenol‐U‐^14^C and o‐methoxyphenol‐U‐^14^C [guaiacol‐(phenyl‐U‐^14^C)].
An improved synthesis of [phenyl-14C(U)] Lawsone
✍ Scribed by Christopher Wright; Giliyar V. Ullas
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- French
- Weight
- 71 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-2135
- DOI
- 10.1002/jlcr.643
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✦ Synopsis
Abstract
Synthesis of ^14^C‐labelled Lawsone or 2‐hydroxy‐1,4‐naphthoquinone was achieved by auto‐oxidation of [phenyl‐^14^C(U)]α‐tetralone; the latter was prepared from [^14^C(U)] benzene in a reaction sequence more convenient than reported earlier. Copyright © 2002 John Wiley & Sons, Ltd.
📜 SIMILAR VOLUMES
## Abstract 2,2′4′‐Trichloro‐[ring U‐^14^C]acetophenone 3 was the key intermediate of this synthesis patterned after the industrial route. An unexpected poor yield was observed during the preparation of 3 by the Friedel‐Crafts reaction of chloroacetyl chloride with 1,3‐dichloro‐[U‐^14^C]benzene 10,
## Abstract Radiolabeled 4‐hydroxycoumarin was synthesized on a microscale by condensing [U‐^14^C]phenol and malonic acid in the presence of anhydrous zinc chloride and phosphorus oxychloride. The yield was 14% on a 0.5 mmol scale at a specific activity of 107 μCi/mmol.
## 0-Ethyl-S-phenyl-ethylphosphonodithioate ( 1 ) a broad spectrum soil insecticide (2) was unqormly labeled in the benzene ring with Carbon-14 to expand the residue and metabolism information (3' gained from previous labelings of this compound ( 4 ) .
In support of a program to develop a treatment for advanced, refractory cutaneous T-cell lymphoma, two differentially [ 14 C]-labeled forms of vorinostat, a histone deacetylase inhibitor, were synthesized for use in metabolism studies.