✦ LIBER ✦

Synthesis of 5-[(4-phenylpiperazin-1-yl)methyl]pyrrolo-[2,3-d]pyrimidine derivatives as potential dopamine D4 receptor ligands

✍ Scribed by Sabine Linz; Reinhard Troschütz

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 426 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440211

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✦ Synopsis

Abstract

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A series of pyrrolo[2,3‐d]pyrimidine Mannich bases of type 9, 12, 15 and 16 have been prepared as potential dopamine D4 receptor ligands. The syntheses start from 4‐aminopyrimidin‐6‐one 3 with pyrrole annulations and Mannich reactions with formaldehyde and phenylpiperazines 8 as new amine components.

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## Abstract For Abstract see ChemInform Abstract in Full Text.