Synthesis of [123I]-8-[4-[2-(5-iodothienyl)]-4-oxobutyl]-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one: A potential dopamine D2 receptor radioligand for SPECT

Synthesis of [123I]-3-(4-iodobenzyl)-1,2

Synthesis of [123I]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one, a potential dopamine D4 ligand for SPECT studies

✍ L. Staelens; R. Oltenfreiter; B. Cornelissen; P. Blanckaert; F. De Vos; D. Defor 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 108 KB 👁 1 views

Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neurotransmission is responsible for the positive

Synthesis of 5-[(4-phenylpiperazin-1-yl)

Synthesis of 5-[(4-phenylpiperazin-1-yl)methyl]pyrrolo-[2,3-d]pyrimidine derivatives as potential dopamine D4 receptor ligands

✍ Sabine Linz; Reinhard Troschütz 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 426 KB

## Abstract magnified image A series of pyrrolo[2,3‐__d__]pyrimidine Mannich bases of type **9, 12, 15** and **16** have been prepared as potential dopamine D4 receptor ligands. The syntheses start from 4‐aminopyrimidin‐6‐one **3** with pyrrole annulations and Mannich reactions with formaldehyde a

ChemInform Abstract: 1-Hydroxy-8-methyl-

ChemInform Abstract: 1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and Its (.+-.)-3-Methyl Homologue: Regioselective Synthesis and in vivo Evaluation as Adjuvants in Leukemia Chemotherapy.

✍ Igor V. Vystorop; Nina P. Konovalova; Tat'yana E. Sashenkova; Elena N. Berseneva 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

## Abstract The condensation reaction of glycine and alanine hydroxamic acids with piperidone (II) regioselectively affords the title spiro compounds (III), which are capable of enhancing sensitivity of P388 and L1210 leukemias in mice models to the known anticancer drugs cisplatin and cyclophospha

Synthesis and radiolabelling of [123I]-4

Synthesis and radiolabelling of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential dopamine D3 antagonist for SPECT studies

✍ L. Staelens; F. Dumont; F. De Vos; R. Oltenfreiter; M. Vandecapelle; R.A. Dierck 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 95 KB 👁 1 views

## Abstract Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neurotransmission is responsible for

Synthesis and radiolabelling of [123I]-4

Synthesis and radiolabelling of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential dopamine D3 antagonist for SPECT studies

✍ L. Staelens; F. Dumont; F. De Vos; R. Oltenfreiter; M. Vandecapelle; R. A. Dierc 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 98 KB 👁 1 views

## Abstract Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neurotransmission is responsible for

ChemInform Abstract: Synthesis of (.+-.)

ChemInform Abstract: Synthesis of (.+-.)-(3R*, 4S*, 4aR*)-4,8-Dihydroxy-3-methyl-3,4,4a,5-tetrahydro-1H-2-benzopyran-1-one.

✍ Kanako Uchida; Hidenori Watanabe; Takeshi Kitahara 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views