✦ LIBER ✦

ChemInform Abstract: 1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and Its (.+-.)-3-Methyl Homologue: Regioselective Synthesis and in vivo Evaluation as Adjuvants in Leukemia Chemotherapy.

✍ Scribed by Igor V. Vystorop; Nina P. Konovalova; Tat'yana E. Sashenkova; Elena N. Berseneva; Alexander V. Chernyak; Boris S. Fedorov; Remir G. Kostyanovsky

Publisher: John Wiley and Sons
Year: 2012
Weight: 31 KB
Volume: 43
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201210152

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The condensation reaction of glycine and alanine hydroxamic acids with piperidone (II) regioselectively affords the title spiro compounds (III), which are capable of enhancing sensitivity of P388 and L1210 leukemias in mice models to the known anticancer drugs cisplatin and cyclophosphamide.

📜 SIMILAR VOLUMES

ChemInform Abstract: 3-Methyl-2-(4-subst

ChemInform Abstract: 3-Methyl-2-(4-substituted phenyl)-4,5-dihydronaphtho[1,2-c]pyrazoles: Synthesis and in vitro Biological Evaluation as Antitumor Agents.

✍ Mohamed S. Al-Saadi; Sherif A. F. Rostom; Hassan M. Faidallah 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

ChemInform Abstract: Synthesis and in vi

ChemInform Abstract: Synthesis and in vitro Evaluation of N-Alkyl-3-hydroxy-3- (2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one Analogues as Potential Anticancer Agents.

✍ Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Nikhil Reddy Madadi; Pete 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

ChemInform Abstract: Synthesis and in-vi

ChemInform Abstract: Synthesis and in-vitro Antimycobacterial Evaluation of 1-(Cyclopropyl/2,4-difluorophenyl/tert-butyl) -1,4-dihydro-8-methyl-6-nitro-4-oxo-7-(substituted secondary amino)quinoline-3-carboxylic Acids.

✍ Palaniappan Senthilkumar; Murugesan Dinakaran; Yogesh Chandraseakaran; Perumal Y 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 43 KB

ChemInform Abstract: Synthesis of Racemi

ChemInform Abstract: Synthesis of Racemic 6,7,8,9-Tetrahydro-3-hydroxy-1H-1-benzazepine-2,5- diones as Antagonists of N-Methyl-D-aspartate (NMDA) and α-Amino- 3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptors.

✍ A. P. GUZIKOWSKI; E. R. WHITTEMORE; R. M. WOODWARD; E. WEBER; J. F. W. KEANA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

ChemInform Abstract: A Novel Synthetic M

ChemInform Abstract: A Novel Synthetic Method of the (VII) (.+-.)-(3aα,8aα)-Ethyl 8β-Hydroxy-6β-methyl-2-oxooctahydro-2H-cyclohepta [b]furan-3α-carboxylate and Its Chemical Transformation to (XIII) (.+-.)-(3aα,8aα) -3α,6β-Dimethyl-3,3a,4,5,6,8a-hexahydro-2H-cyclohepta [b]furan-2-one, (+)- (XIV) and (-)- (XIV) -7β-(2-Acetoxy-1α-methylethyl) -4β-methyl-2-cyclohepten-1β-ol, and (+)- (XVII) and (-)- (XVII) -7β-(2-Acetoxy-1α-methylethyl) -4β-methyl-2-cyclohepten-1-one. Possible Common Synthetic Intermediates for Pseudoguaianolides, 4,5-Secopseudoguaianolides, Guaianolides, 4,5-Secoguaianolides, and Octalactins.

✍ F. SHIMOMA; H. KUSAKA; K. WADA; H. AZAMI; M. YASUNAMI; T. SUZUKI; H. HAGIWARA; M 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 51 KB 👁 1 views

ChemInform Abstract: Methyl N-(Benzylsul

ChemInform Abstract: Methyl N-(Benzylsulfonyl)oxamate as a Probable Intermediate in the Synthesis of 4-Hydroxy-5-phenyl-3(2H)-isothiazolone 1,1-Dioxide from Phenylmethanesulfamide and Dimethyl Oxalate in the Presence of Bases.

✍ S. G. Zlotin; A. I. Gerasyuto 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Methyl N-(Benzylsulfonyl)oxamate as a Probable Intermediate in the Synthesis of 4-Hydroxy-5-phenyl-3(2H)-isothiazolone 1,1-Dioxide from Phenylmethanesulfamide and Dimethyl Oxalate in the Presence of Bases. -The base-mediated formation of the title isothiazolone dioxide (III) from phenylmethanesulfa