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Synthesis of 5-methyl-4-oxo-2-(coumarin-3-yl)-N-aryl-3,4-dihydrothieno[2,3-d]-pyrimidine-6-carboxamides

✍ Scribed by Sergiy M. Kovalenko; Sergiy V. Vlasov; Valentin P. Chernykh

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 150 KB
Volume: 18
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.20303

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✦ Synopsis

Abstract

Possible approaches to synthesis of 5‐methyl‐4‐oxo‐2‐(coumarin‐3‐yl)‐N‐aryl‐3,4‐dihydrothieno[2,3‐d]pyrimidine‐6‐carboxamides 4 have been discussed. It is shown that the preferable approach is cyclization of 2‐iminocoumarin‐3‐carboxamides 1, utilizing 5‐amino‐3‐methyl‐N^2^‐arylthiophene‐2,4‐dicarboxamides 2 as binucleophilic reagents. The proposed procedure allowed us to easily obtain 4 in two stages, using common reagents. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:341–346, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20303

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