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Synthesis of 4-substituted azepino[3,4-b]indole-1,5-diones

✍ Scribed by Julien Perron; Benoı̂t Joseph; Jean-Yves Mérour

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 213 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)00979-7

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✦ Synopsis

Monoor dibromo derivatives 2 and 3 were prepared by an efficient two-step route from 10-methyl-azepino [3,4-b]indole-1,5dione 1. Elimination reaction on 2 gave access to 4-bromo-10-methyl-2H,10H-azepino[3,4-b]indole-1,5-diones 4. Finally, 4-substituted 10methyl-2H,10H-azepino [3,4-b]indole-1,5-diones 6 -14 were synthesised in good yields from 4 via palladium-mediated cross-coupling reactions.

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