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Preparation and reactivity of 5-substituted azepino[3,4-b]indoles

✍ Scribed by C. Montagne; N. Laurent; B. Joseph; J.-Y. Mérour

Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
179 KB
Volume
42
Category
Article
ISSN
0022-152X

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✦ Synopsis

Preparation of the 5-substituted azepino [3,4-b]indole core structure can be realised through a catalytic Heck reaction. The scope and limitations of this methodology are reported. The reactivity of di-tert-butyl 5ethoxycarbonylmethylene-1,3,4,5-tetrahydro-1-oxoazepino[3,4-b]indole-2,10-dicarboxylate (1) was investigated in order to prepare the indole analogue of hymenialdisine and derivatives.

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