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Synthesis of Substituted Azepino[3,4-b]indole-1,5-diones

✍ Scribed by Julien Perron; Benoît Joseph; Jean-Yves Mérour

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
164 KB
Volume
2004
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

Cyclic β‐amino esters 4, obtained from lactams, were condensed with indole‐2‐carbonyl chloride to afford the corresponding amides. Similarly, unusual conditions led to cyclisation at the 3‐position of the indole moiety in the presence of __p__TSA and ethylene glycol to afford previously unknown pentacyclic derivatives 12 and 15. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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