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Synthesis of 4-nitro-1-(trialkylsilylalkyl)imidazoles

✍ Scribed by Földeák, Sándor ;Molnár, Mária ;L??kös, Magdalena

Book ID: 102366343
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 129 KB
Volume: 1994
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.199419940216

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✦ Synopsis

Abstract

1‐(2‐Hydroxyethyl)‐2‐methyl‐5‐nitroimidazole (1) reacts with haloalkyltrialkylsilanes [Hal(CH~2~)~n~SiMe~2~R] to give 4‐nitroimidazole derivatives 3 and acetaldehyde. This process involves at least two reaction steps, N‐alkyl quaternization and elimination of the hydroxyethyl group. magnified image

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