Synthesis of 4-aroyl-5-nitro-1H-imidazoles and 4-aroyl-5-aminoimidazoles
โ Scribed by J. Donald Albright; Daniel B. Moran
- Book ID
- 112128254
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1986
- Tongue
- English
- Weight
- 495 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-152X
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๐ SIMILAR VOLUMES
## Abstract __Cine__ nucleophilic substitution of 1,4โdinitroimidazole and its 2โmethyl derivative with nitrogenโ15 or carbonโ13 potassium cyanides afforded, respectively, labelled 4(5)โnitroโ1Hโimidazoleโ5(4)โcarbonitriles. Detailed mass spectra analysis led to the conclusion that during fragmenta
We report here a convenient and efficient two-step synthesis of 1-aryl-2-arylamino-4-alkyl/phenyl-5aroyl-1H-imidazoles from easily available amidinothioureas. Guanylation of amidinothioureas 1 using mercury(II) chloride as a thiophile yielded amidinoguanidines 2, which reacted with various phenacyl