✦ LIBER ✦

A facile synthesis of structurally novel 1-aryl-2-arylamino-4-alkyl/phenyl-5-aroyl-1H-imidazoles from amidinothioureas

✍ Scribed by Jitendra C. Kaila; Arshi B. Baraiya; Kamala K. Vasu; V. Sudarsanam

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 172 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.10.012

No coin nor oath required. For personal study only.

✦ Synopsis

We report here a convenient and efficient two-step synthesis of 1-aryl-2-arylamino-4-alkyl/phenyl-5aroyl-1H-imidazoles from easily available amidinothioureas. Guanylation of amidinothioureas 1 using mercury(II) chloride as a thiophile yielded amidinoguanidines 2, which reacted with various phenacyl bromides under mild conditions to afford the corresponding diversely functionalized imidazoles 3 in moderate to good yields.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Facile Synthesis

ChemInform Abstract: A Facile Synthesis of Structurally Novel 1-Aryl-2-arylamino-4-alkyl/phenyl-5-aroyl-1H-imidazoles from Amidinothioureas.

✍ Jitendra C. Kaila; Arshi B. Baraiya; Kamala K. Vasu; V. Sudarsanam 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

A Facile One-Pot Synthesis of Novel Subs

A Facile One-Pot Synthesis of Novel Substituted 1,2,3,4-Tetrahydropyrimidine. Part 2. Synthesis of 1-(Aralkyl/aryl)-3- (alkyl/aralkyl/aryl)-5-aroyl-1,2,3,4-tetrahydropyrimidines.

✍ Kaushik Chanda; Milan Ch. Dutta; Enamul Karim; Jai N. Vishwakarma 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 20 KB 👁 1 views

A facile one-pot synthesis of novel subs

A facile one-pot synthesis of novel substituted 1,2,3,4-tetrahydropyrimidine, part 2: Synthesis of 1-(aralkyl/aryl)-3-(alkyl/aralkyl/aryl)-5-aroyl-1,2,3,4-tetrahydropyrimidines

✍ Kaushik Chanda; Milan Ch. Dutta; Enamul Karim; Jai N. Vishwakarma 📂 Article 📅 2004 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 106 KB 👁 1 views

## Abstract 1‐(Aralkyl/aryl)‐3‐(alkyyaralkyl)‐5‐aroyl‐1,2,3,4‐tetrahydropyrimidines (**2a‐c**) have been synthesized by dethiomethylation of 5‐aroyl‐6‐methylthio‐1,2,3,4‐tetrahydropyrimidines (**1a‐c**). An alternative one‐pot synthetic strategy has been developed for the title compounds **2a‐t** b

Efficient Synthesis of 4-(3-Fluoro-5-{ [

Efficient Synthesis of 4-(3-Fluoro-5-{ [4-(2-methyl-1H-imidazol-1-yl)benzyl] oxy}phenyl)tetrahydro-2H-pyran-4-carboxamide, a Novel 5-Lipoxygenase Inhibitor.

✍ Takashi Mano; Rodney W. Stevens; Kazunari Nakao; Yoshiyuki Okumura; Kiyoshi Kawa 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 9 KB 👁 1 views

A new facile synthesis of 5-aryl-4-trifl

A new facile synthesis of 5-aryl-4-trifluoroacetyl-6-trifluoromethyl-3,4-dihydro-2H-1,3,4-oxadiazines from arylaldehydes

✍ Yasuhiro Kamitori; Masaru Hojo; Ryōichi Masuda; Yoshihiko Kawamura; Kazuyoshi Ka 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 125 KB

By reaction with an excess of trifluoroacetic anhydride, title compounds 4 were synthesized from C-trifluoroacetylated hydrazones 1 which are readily obtainable by trifluoroacetylation of arylaldehyde dimethylhydrazones. Oxadiazine derivatives have attracted much attention of organic chemists from i

Synthesis and Pharmacological Investigat

Synthesis and Pharmacological Investigation of Novel 1-Alkyl-4-(4-substituted aryl/heteroaryl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones as a New Class of H1-Antihistaminic Agents.

✍ Veerachamy Alagarsamy; Mangae Ram Yadav; Rajani Giridhar 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views