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A facile one-pot synthesis of novel substituted 1,2,3,4-tetrahydropyrimidine, part 2: Synthesis of 1-(aralkyl/aryl)-3-(alkyl/aralkyl/aryl)-5-aroyl-1,2,3,4-tetrahydropyrimidines

✍ Scribed by Kaushik Chanda; Milan Ch. Dutta; Enamul Karim; Jai N. Vishwakarma

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
106 KB
Volume
41
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

1‐(Aralkyl/aryl)‐3‐(alkyyaralkyl)‐5‐aroyl‐1,2,3,4‐tetrahydropyrimidines (2a‐c) have been synthesized by dethiomethylation of 5‐aroyl‐6‐methylthio‐1,2,3,4‐tetrahydropyrimidines (1a‐c). An alternative one‐pot synthetic strategy has been developed for the title compounds 2a‐t by the reaction of enaminones 3 with pri mary amine and formaldehyde in refluxing methanol in good yields.

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A facile one-pot synthetic strategy has been developed for novel [alkanediylbis(3-alkyl/aralkyl/ aryl-3,6dihydropyrimidine-1,5(2H)-diyl)]bis(arylmethanones) 2a-c, 2e-m and [1,4-phenylenebis(3-phenyl-3,6dihydropyrimidine-1,5(2H)-diyl)]bis(phenylmethanone) 2d by refluxing enaminones 1a-f in methanol w