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Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinonesvia β-lactam intermediates on the solid-phase

✍ Scribed by Yazhong Pei; Richard A. Houghten; John S. Kiely

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
241 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of 3,4-dihydro-2(IH)-quinolinones has been accomplished through the rearrangement of ~lactam intermediates on the solid-phase. The ~-laetam intermediates were constructed through [2+2] cycloadditions between ketenes and imines on the solid-phase. A library of 4,140 dihydroquinolinones has been produced using this synthetic process.

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