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Solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones

✍ Scribed by Qun Sun; Xiaoming Zhou; Donald J Kyle

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
113 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones is described. Starting from Rink resin, acylation with 4-bromomethyl-3-nitrobenzoic acid and amination with primary amines, reduction with tin chloride and cyclization, the desired 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones have been synthesized in good yield and high purity.

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