✦ LIBER ✦

Synthesis of [4-3H]-2-pyrrolidinone, [4-3H]-N-methyl-2-pyrrolidinone and N-[14C-methyl]-2-pyrrolidinone

✍ Scribed by David A. Wells; James E. Chaney; George A. Digenis

Publisher: John Wiley and Sons
Year: 1985
Tongue: French
Weight: 544 KB
Volume: 22
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580220409

No coin nor oath required. For personal study only.

✦ Synopsis

An efficient synthesis of 2-pyrrolidinone and N-methyl-2-pyrrolidinone was developed in which the compounds can be labeled with tritium at either the 3-and 4-positions or the 4-position of the lactam ring. Cyclization of [2 3-3Hl-yarninobutyric acid (GABA) yielded [ 3, $-$I -2pyrrolidinone and cyclization of [ 3 -HI-GABA, prepared by acid-catalyzed ex hange of tritium from by methylation of [3,4-IH] -2-pyrrolidinone using phase transfer catalysis, followed by basecatalyzed tritium exchange.

iodide and 2-pyrrolidinone, also using phase transfer catalysis.

-3H] -GABA, yielded [4-s HI -2-pyrrolidinone.

📜 SIMILAR VOLUMES

Synthesis of [2,3,4,5-14C]-1-vinyl-2-pyr

Synthesis of [2,3,4,5-14C]-1-vinyl-2-pyrrolidinone

✍ George A. Digenis; J. S. McClanahan; Pei-Lin Chen 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 257 KB 👁 1 views

## Abstract An efficient small scale synthesis of ^14^C labeled 1‐vinyl‐2‐pyrrolidinone (NVP) is described. The cyclization of commercially available [1,2,3,4‐^14^C]‐γ‐aminobutyric acid (GABA) gives [2,3,4,5‐^14^C]‐2‐pyrrolidinone which is vinylized with vinyl acetate via a sodium tetrachloropallad

Synthesis of 2-pyrrolidinone-5-14C

✍ A. J. Villani; W. L. Mendelson; D. W. Blackburn 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 197 KB

## Abstract A convenient synthesis of the pharmacological intermediate 2‐pyrrolidione‐5‐^14^C, was developed using potassium cyanide ^14^C as starting material. Potassim cyanide‐^14^C was converted to 2‐pyrrolidinone‐5‐^14^C in an overall 56% radiochemical yield.

Photochemical Synthesis of N-Substituted

Photochemical Synthesis of N-Substituted 3-Hydroxy-2-pyrrolidinones.

✍ Markus Obkircher; Wolfgang Seufert; Bernd Giese 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 19 KB 👁 1 views

Facile Addition of Ketones to Activated

Facile Addition of Ketones to Activated Isoquinolines Using N-Methyl-2-pyrrolidinone.

✍ J. S. Yadav; B. V. S. Reddy; Manoj K. Gupta; I. Prathap; Uttam Dash 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 28 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Synthesis of 3-(o-Chlorophenyl)-2-methyl

Synthesis of 3-(o-Chlorophenyl)-2-methyl-4 (3H)-quinazolinone-2 and 4-14C

✍ E. J. Merrill 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 French ⚖ 227 KB 👁 1 views

Synthesis of 4-[2-(DI-n-propylamino)ethy

Synthesis of 4-[2-(DI-n-propylamino)ethyl]-[2-14C]-2(3H)-indolone

✍ J. Richard Heys 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 240 KB

4-[2-(Di -n-pr yl amino)et hyl l-2 (3H)-indolone ( 1 ) labeled with ? !C at C2 was prepared by a simple and efficient procedure involving carbonation o f a stabilized benzvllithium species. fol owed by ring closure under hydrolytic conditions.