## Synthesis of the title compound ( 5 ) . an histamine H2 -receptor antagonist, is described. Treatment of 3-(3-[2.6-C1-piperidinomethylphenoxv)propylamine(l)l with 3-amino-4-methoxy-l,2,5-thiadiazole-1-oxide2 produced 3-amino-4-13-0-[ 2,6-"C]piperidinomethylphenoxy)propylamino~-1,2,5-thiadiazole
Synthesis of 4-[2-(DI-n-propylamino)ethyl]-[2-14C]-2(3H)-indolone
β Scribed by J. Richard Heys
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 240 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
4-[2-(Di -n-pr yl amino)et hyl l-2 (3H)-indolone ( 1 ) labeled with ? !C at C2 was prepared by a simple and efficient procedure involving carbonation o f a stabilized benzvllithium species. fol owed by ring closure under hydrolytic conditions.
π SIMILAR VOLUMES
## Abstract 4β|2β(Dimethylamino)ethylβ2β^14^C| phenol (hordenineβΞ±β^14^C) has been synthesised in three steps from |^14^C|potassium cyanide and __p__βbenzyloxybenzyl chloride which in turn was obtained in four steps from __p__βhydroxybenzoic acid.
HCl) was synthesized through a straightforward six-step sequence from the readily available [ 14 C-carbonyl]methyl salicylate (2). The overall radiochemical yield of the 1 . 2 HCl from 2 was 10.5%, and its radiochemical purity was 98.8%.
## Abstract The synthesis of 1,1,3,3βtetraethoxypropaneβ1,2,3β^14^C~3~ from uniformly labeled paraldehyde is described. The synthesis involves three steps and proceeds in an overall yield of 25%. The final product is greater than 95% radiochemically pure and it is stable indefinitely when stored as