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Synthesis of [3H] vardenafil, Levitra®, using a new labeling technique

✍ Scribed by U. Pleiss

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
133 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Tritium was introduced into the new orally active, selective phosphodiesterase type V (PDE V) inhibitor vardenafil (Levitra^®^), by reduction of a suitable amide precursor with freshly prepared lithium aluminum tritide. A specific activity of 52.7 Ci/mmol (1.95 TBq/mmol) was achieved. In order to overcome the usual technical difficulties during the preparation of complex tritides a new and easy labeling technique which has considerable potential for various tritia‐tion procedures, was developed. Copyright © 2003 John Wiley & Sons, Ltd.

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