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Synthesis of a new class of retinoid, 3H-labelled TTNPB, 1 with a high specific activity

✍ Scribed by Sung W. Rhee; Joseph I. Degraw; Heinz H. Kaegi

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
294 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

Synthetic procedures for tritiation of a retinoidal benzoic acid derivative, (E)-4-[ 2-( 5,6 , 7,8-n?trahydro-5,5,8,8-tetramethyl-2-naphthalenyl-6, 7-'ii2 1-1propenyll-benzoic acid, (TTNPB), are described. Tritium was introduced by catalytic hydrogenation. The final product, TTNPB-3H2 (2). had a specific activity of 24.1 Ci/mmole and a radiochemical purity of 95.6%.

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