## Abstract A rapid method of noβcarrierβadded radiobrominations of Aβring estrogens has been demonstrated. The method employs Nβchlorosuccinimide and high specific activity sodium bromideβ77 to generate an electrophilic brominating agent, which when reacted with phenolic steroids, yields three pri
A one step synthesis of ring labelled melatonin-3H with high specific activity
β Scribed by Yu-Ying Liu; Martha Minich
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 231 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
A mixture of brominated melatonin derivatives has been synthesized for use as starting material for preparation of ring tritium labelled melatonin by catalytic hydrogenolysis. The high specific activity obtained makes this product useful in radioimmunoassay studies.
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Tritium labelled 8-chloro-l-[(dimethylamino)methyl]-6-phenyl-4H-striazolo[4,3-a][ 1,4]benzodiazepine was prepared from [3Hlbromomethane and 8chloro-I -[(N-methylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][ 1.4lbenzodiazepine. The latter compound was efficiently obtained from 8-chloro-6-phenyl- 4H-s-
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