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Synthesis of 1-hydroxy-3-[3-3H-(4-chlorophenyl)-2-piperidone. Labelling of a new antiinflammatory hydroxamic acid

✍ Scribed by P. H. Bovy; M. Callaeri; C. Gillet; J. M. De Decker; M. Winand

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
334 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

Compound 1, synthezized as a potential topical antiinflammatory agent,has been labelled with tritium on the benzene ring in a position neighboring a chlorine atom.

sis. Selective catalytic iodine-tritium replacement was achieved under mild reaction conditions.

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