Synthesis of 3′-deoxynucleosides III. Synthesis of 9-(3-deoxyaldofuranosyl) adenines derived from 3-deoxy-D-mannose and 3-deoxy-D-galactose
✍ Scribed by J. Prokop; Daniel H. Murray
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 621 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3549
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Condensation of Z-deoxy-~-ribose with nitromethane gave, after deionization, a syrupy mixture of epimeric l-nitro-1,3-dideoxy-hexitols. Acid hydrolysis under Nef reaction conditions produced a mixture of 3-deoxy-~-glucose and 3-deoxy-m mannose, separable by cellulose chromatography or fractional cry
As part of a study of the effects of sugar analogs on glycoprotein biosynthesis'V2, it was necessary to prepare 3-deoxy-D-ribo-hexose (4) and 3-deoxy-D-arabino-hexose (5). Several satisfactory syntheses of these deoxy sugars have been reported3-7. For example, 3-deoxy-D-Cbo-hexose may be obtained by
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