Synthesis of 3′-deoxynucleosides I. Synthesis of 9-(3-deoxyaldofuranosyl) adenines derived from 3-deoxy-d-galactose
✍ Scribed by J. Prokop; Daniel H. Murray
- Publisher
- John Wiley and Sons
- Year
- 1965
- Tongue
- English
- Weight
- 646 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3549
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📜 SIMILAR VOLUMES
Condensation of Z-deoxy-~-ribose with nitromethane gave, after deionization, a syrupy mixture of epimeric l-nitro-1,3-dideoxy-hexitols. Acid hydrolysis under Nef reaction conditions produced a mixture of 3-deoxy-~-glucose and 3-deoxy-m mannose, separable by cellulose chromatography or fractional cry
A practical synthesis of 9-(2,3-dideoxy-2-fluoro-b-D-threo-pentofuranosyl)adenine (1, FddA) via a 6-chloro-9-(3-deoxyb-D-erythro-pentofuranosyl)-9H-purine (6) is described. Fluorination at the C2%-b position of the purine 3%-deoxynucleoside was improved by the introduction of 6-chloro group, and pro