The title compound, CGS 148248, was synthesized with a '%-label in the azepine ring in 14 steps starting with l-bromo-3-phenylpropane (1> and K1%N in an overall yield of 1.31%. The reaction of I with K 1 k N yielded the nitrile 2 which upon hydrolysis followed by ring closure gave a-tetral~ne-l-~~c
Synthesis of 3-[4-(1-ethoxycarbonyl-1-methylethoxy)phenyl]-5-(3-pyridyl)-1,2,4-[3-14C]oxadiazole (AT-308-14C)
✍ Scribed by Nobuyoshi Hayashi; Tadashi Toga; Akio Miyake
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 167 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2135
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## Abstract The synthesis from carbon‐^14^C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near
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