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Synthesis of 3-[18F]fluoromethyl-BTCP and evaluation as a potential PET radioligand for the dopamine transporter in baboons

✍ Scribed by Ponchant, M.; Varastet, M.; Hantraye, P.; Chicheportiche, R.; Kamenka, J.M.; Crouzel, C.

Book ID: 124133782
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 611 KB
Volume: 20
Category: Article
ISSN: 0969-8051
DOI: 10.1016/0969-8051(93)90159-R

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## Abstract In an attempt to visualize the NMDA glutamatergic receptors and after checking the biological activity of the cold 3‐fluoromethyl‐TCP 3, 3‐[^18^F]‐fluoro‐methyl‐TCP 4 was synthesized by a nucleophilic substitution of 3‐bromomethyl‐TCP 5 with [^18^F^−^].