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Synthesis of 3-[18F]-fluoromethyl-TCP1, A potential tool for pet study of the nmda receptor channel complex

✍ Scribed by M. Ponchant; M. Kamenkaj; C. Crouzel

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
241 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

In an attempt to visualize the NMDA glutamatergic receptors and after checking the biological activity of the cold 3‐fluoromethyl‐TCP 3, 3‐[^18^F]‐fluoro‐methyl‐TCP 4 was synthesized by a nucleophilic substitution of 3‐bromomethyl‐TCP 5 with [^18^F^−^].

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