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Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter

✍ Scribed by Hongwen Qiao; Lin Zhu; Brian P. Lieberman; Zhihao Zha; Karl Plössl; Hank F. Kung


Book ID
116318568
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
231 KB
Volume
22
Category
Article
ISSN
0960-894X

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A series of PET imaging studies were conducted with two fluorine-18-labeled tropane analoges, [(18)F](+)-FTT and [(18)F](+)-FCT. Both compounds possessed a high affinity and selectivity for the dopamine transporter and had a higher accumulation in the basal ganglia, a brain region having a high dens