Synthesis of 3′-1,2,4-triazolo- and 3′-1,3,4-thiadiazoliminothymidines
✍ Scribed by Yaseen A. Al-Soud; Najim A. Al-Masoudi
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 114 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1042-7163
- DOI
- 10.1002/hc.10146
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✦ Synopsis
Abstract
New 5′‐acetyl‐3′‐1,3,4‐thiadiazoliminothymidines 11, 14 were prepared, via spontaneous rearrangments, by cycloaddition of 5′‐acetyl‐3′‐deoxy‐3′‐isothiocyanatothymidine 9 with 1‐aza‐2‐azoniaallene hexachloantimonates. Similary, 3′‐cyano analogue 19 was reacted with the same cumulenes to furnish 3′‐1,2,4‐triazolo‐thymidines 22, 24, and 26. Deblocking of the acylated products afforded the free nucleosides. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:298–303, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10146
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Synthese von 2H-1,2,3-Triazolo[4,5-~][1,2,4]triazolo[4,3-a]pyridinen und verwandten Systemen Zur Herstellung des 2H-1,2,3-Triazolo[4,5-c]pyridin-4(5H)-ons 4 wurde 2-Phenyl-2H-l,2,3triazol-4-carbaldehyd (1) zunichst in die Acrylsiiure 2 umgewandelt und letztere dann nach vorausgehender Curtius-Umlage