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Synthesis of 3′-1,2,4-triazolo- and 3′-1,3,4-thiadiazoliminothymidines

✍ Scribed by Yaseen A. Al-Soud; Najim A. Al-Masoudi


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
114 KB
Volume
14
Category
Article
ISSN
1042-7163

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✦ Synopsis


Abstract

New 5′‐acetyl‐3′‐1,3,4‐thiadiazoliminothymidines 11, 14 were prepared, via spontaneous rearrangments, by cycloaddition of 5′‐acetyl‐3′‐deoxy‐3′‐isothiocyanatothymidine 9 with 1‐aza‐2‐azoniaallene hexachloantimonates. Similary, 3′‐cyano analogue 19 was reacted with the same cumulenes to furnish 3′‐1,2,4‐triazolo‐thymidines 22, 24, and 26. Deblocking of the acylated products afforded the free nucleosides. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:298–303, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10146


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